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|a Traditional natural river sand is used as a fine aggregate for concrete, but due to the severe environmental situation in recent years, many places have asked for a ban or restriction on the extraction of river sand. This has resulted in an increasing demand for concrete using machine-made sand instead of natural sand. The estimation and prediction of the compressive strength of concrete is very important in civil engineering applications. In this investigation, a Box–Behnken test model was established to analyze the effect of stone powder (SP), pulverized fuel ash (PFA), and silica fume (SF) contents on the compressive strength of manufactured sand concrete using response surface methodology (RSM). A prediction model for the compressive strength of manufactured sand concrete was developed using multiple regression analysis with SP, PFA, and SF content as factors and compressive strength as the response value. In addition, the interaction of stone powder (SP), pulverized fuel ash (PFA), and silica fume (SF) content was analyzed according to the response surface and contour. The investigation showed that for single factors, SP had the greatest effect on the compressive strength of the manufactured sand concrete, with PFA having the second greatest effect, and SF the least; for the interactions, SP and PFA had the most significant effect, and the interaction between SP and SF and PFA and SF had the same effect on the compressive strength. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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