NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

Background: Thiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression. The nudix hydrolase 15 (NUDT15) genetic polymorphism is strongly associated with the tolerance and myelosu...

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Bibliographic Details
Main Authors: Amat, G. (Author), Chen, C. (Author), Chen, R. (Author), Hu, W. (Author), Shen, S. (Author), Tang, Y. (Author), Tian, X. (Author), Xie, Y. (Author), Zhang, F. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
Dai
hematotoxicity
Kirghiz
mercaptopurine
NUDT15 polymorphism
Uighur
Online Access:View Fulltext in Publisher

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