Receptor-Interacting Protein Kinase 3 Inhibition Relieves Mechanical Allodynia and Suppresses NLRP3 Inflammasome and NF-κB in a Rat Model of Spinal Cord Injury

Receptor-Interacting Protein Kinase 3 Inhibition Relieves Mechanical Allodynia and Suppresses NLRP3 Inflammasome and NF-κB in a Rat Model of Spinal Cord Injury

Background: Neuroinflammation is critical in developing and maintaining neuropathic pain after spinal cord injury (SCI). The receptor-interacting protein kinase 3 (RIPK3) has been shown to promote inflammatory response by exerting its non-necroptotic functions. In this study, we explored the involve...

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Bibliographic Details
Main Authors: Cao, Z.-X (Author), Han, J. (Author), Sun, T. (Author), Wang, J.-N (Author), Xue, S. (Author), Yang, W.-J (Author), Zhao, Q.-X (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
GSK872
neuropathic pain after spinal cord injury
NLRP3 inflammasome
nuclear factor-kappa B (NF-κB)
receptor-interacting protein kinase 3
Online Access:View Fulltext in Publisher

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