The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats

The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats

Propofol addiction has been detected in humans and rats, which may be facilitated by stress. Corticotropin-releasing factor acts through the corticotropin-releasing factor (CRF) receptor-1 (CRF1R) and CRF2 receptor-2 (CRF2R) and is a crucial candidate target for the interaction between stress and dr...

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Bibliographic Details
Main Authors:	Chen, Z. (Author), Dong, Z. (Author), Huang, B. (Author), Jiang, C. (Author), Li, Y. (Author), Lian, Q. (Author), Wu, B. (Author), Xiang, S. (Author), Zhang, G. (Author), Zhou, W. (Author)
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021
Subjects:	addiction adult analysis of variance animal experiment animal tissue antalarmin antisauvagine Article controlled study corticotropin releasing factor antagonist corticotropin releasing factor receptor 1 CRF D1 receptor drug antagonism drug brain level drug receptor binding drug self administration locomotion male microinjection mifepristone nonhuman pH physiological stress polyacrylamide gel electrophoresis post hoc analysis propofol protein expression protein processing rat stress sucrose unclassified drug Western blotting
Online Access:	View Fulltext in Publisher

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