The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats

The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats

Propofol addiction has been detected in humans and rats, which may be facilitated by stress. Corticotropin-releasing factor acts through the corticotropin-releasing factor (CRF) receptor-1 (CRF1R) and CRF2 receptor-2 (CRF2R) and is a crucial candidate target for the interaction between stress and dr...

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Bibliographic Details
Main Authors: Chen, Z. (Author), Dong, Z. (Author), Huang, B. (Author), Jiang, C. (Author), Li, Y. (Author), Lian, Q. (Author), Wu, B. (Author), Xiang, S. (Author), Zhang, G. (Author), Zhou, W. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
addiction
adult
analysis of variance
animal experiment
animal tissue
antalarmin
antisauvagine
Article
controlled study
corticotropin releasing factor antagonist
corticotropin releasing factor receptor 1
CRF
D1 receptor
drug antagonism
drug brain level
drug receptor binding
drug self administration
locomotion
male
microinjection
mifepristone
nonhuman
pH
physiological stress
polyacrylamide gel electrophoresis
post hoc analysis
propofol
protein expression
protein processing
rat
stress
sucrose
unclassified drug
Western blotting
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