Brain Network to Placebo and Nocebo Responses in Acute Experimental Lower Back Pain: A Multivariate Granger Causality Analysis of fMRI Data

Brain Network to Placebo and Nocebo Responses in Acute Experimental Lower Back Pain: A Multivariate Granger Causality Analysis of fMRI Data

Background and Objective: Placebo and nocebo responses are widely observed. Herein, we investigated the nocebo hyperalgesia and placebo analgesia responses in brain network in acute lower back pain (ALBP) model using multivariate Granger causality analysis (GCA). This approach analyses functional ma...

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Bibliographic Details
Main Authors: Cai, G. (Author), Cui, S. (Author), Huang, S. (Author), Shi, Y. (Author), Wu, W. (Author), Yang, J. (Author), Zeng, Y. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
analgesia
anterior cingulate
anxiety
Article
brain region
caudate nucleus
dopamine
dorsolateral prefrontal cortex
emotion
female
functional magnetic resonance imaging
GCA
Granger causality analysis
human
human experiment
hyperalgesia
insula
low back pain
male
multivariate analysis
nerve cell network
nocebo effect
nocebo hyperalgesia
normal human
opioid
placebo analgesia
placebo effect
reward
reward system
secondary somatosensory cortex
supplementary motor area
thalamus
visual analog scale
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