Synaptic connectivity in medium spiny neurons of the nucleus accumbens: A sex-dependent mechanism underlying apathy in the HIV-1 transgenic rat

Synaptic connectivity in medium spiny neurons of the nucleus accumbens: A sex-dependent mechanism underlying apathy in the HIV-1 transgenic rat

Frontal-subcortical circuit dysfunction is commonly associated with apathy, a neuropsychiatric sequelae of human immunodeficiency virus type-1 (HIV-1). Behavioral and neurochemical indices of apathy in the nucleus accumbens (NAc), a key brain region involved in frontal-subcortical circuitry, are inf...

Full description

Bibliographic Details
Main Authors:	Booze, R.M (Author), Cook, A.K (Author), League, A.F (Author), Li, H. (Author), Mactutus, C.F (Author), McLaurin, K.A (Author)
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018
Subjects:	adrenergic transmission animal cell animal experiment animal model animal tissue apathy Apathy Article Biological sex brain region cell population cell volume cellular distribution connectome controlled study dendritic spine Diagnostic classification Discriminant function analysis Dopamine female functional connectivity glutamic acid HIV-1 transgenic rat Human immunodeficiency virus 1 long term exposure male medium spiny neuron Medium spiny neurons nerve cell membrane nonhuman nucleus accumbens rat sex difference sexual development transgene transgenic rat viral protein
Online Access:	View Fulltext in Publisher

Similar Items

Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat
by: Kristen A. McLaurin, et al.
Published: (2018-11-01)

Distribution and compartmental organization of GABAergic medium-sized spiny neurons in the mouse Nucleus Accumbens
by: Giuseppe eGangarossa, et al.
Published: (2013-02-01)

Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease
by: Benjamin R. Miller, et al.
Published: (2010-01-01)

Sex Differences in Medium Spiny Neuron Excitability and Glutamatergic Synaptic Input: Heterogeneity Across Striatal Regions and Evidence for Estradiol-Dependent Sexual Differentiation
by: Jinyan Cao, et al.
Published: (2018-04-01)

An improved BAC transgenic fluorescent reporter line for sensitive and specific identification of striatonigral medium spiny neurons
by: Kristen eAde, et al.
Published: (2011-06-01)

Unravelling the differential functions and regulation of striatal neuron sub-populations in motor control, reward and motivational processes
by: Sabrina eEna, et al.
Published: (2011-07-01)

Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens
by: Braulio Muñoz, et al.
Published: (2018-07-01)

Prolonged Consumption of Sucrose in a Binge-Like Manner, Alters the Morphology of Medium Spiny Neurons in the Nucleus Accumbens Shell.
by: Paul M Klenowski, et al.
Published: (2016-03-01)

Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome
by: Byron Chen, et al.
Published: (2017-08-01)

Sex Matters: Robust Sex Differences in Signal Detection in the HIV-1 Transgenic Rat
by: Kristen A. McLaurin, et al.
Published: (2017-11-01)

Response learning stimulates dendritic spine growth on dorsal striatal medium spiny neurons
by: Briones, B.A, et al.
Published: (2018)

Spatial distribution of D1R- and D2R-expressing medium-sized spiny neurons differs along the rostro-caudal axis of the mouse dorsal striatum
by: Giuseppe eGangarossa, et al.
Published: (2013-07-01)

Striatal Distribution and Cytoarchitecture of Dopamine Receptor Subtype 1 and 2: Evidence from Double-Labeling Transgenic Mice
by: Keke Ren, et al.
Published: (2017-08-01)

Striatal circuit development and its alterations in Huntington's disease
by: Margaux Lebouc, et al.
Published: (2020-11-01)

Excitation of medium spiny neurons by ‘inhibitory’ ultrapotent chemogenetics via shifts in chloride reversal potential
by: Stephanie C Gantz, et al.
Published: (2021-04-01)

The translational study of apathy – an ecological approach
by: Flurin eCathomas, et al.
Published: (2015-09-01)

Differential Protein Expression in Striatal D1- and D2-Dopamine Receptor-Expressing Medium Spiny Neurons
by: M. Shahid Mansuri, et al.
Published: (2020-10-01)

Susceptibility of spiny rats (Proechimys semispinosus) to Leishmania (Viannia) panamensis and Leishmania (Leishmania) chagasi
by: BL Travi, et al.
Published: (2002-09-01)

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease
by: Anne B. Rocher, et al.
Published: (2016-02-01)

Neurorestoration of Sustained Attention in a Model of HIV-1 Associated Neurocognitive Disorders
by: Landhing M. Moran, et al.
Published: (2019-08-01)

Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
by: Svetlana M. Molchanova, et al.
Published: (2018-01-01)

Measurement of Spine Density in Mouse Models of Hypodopaminergia
by: Bermejo, Marie Kristel
Published: (2013)

Measurement of Spine Density in Mouse Models of Hypodopaminergia
by: Bermejo, Marie Kristel
Published: (2013)

A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types
by: Yasuyuki Shima, et al.
Published: (2016-03-01)

Reduced Expression of GABAA Receptor Alpha2 Subunit Is Associated With Disinhibition of DYT-THAP1 Dystonia Patient-Derived Striatal Medium Spiny Neurons
by: Selma Staege, et al.
Published: (2021-05-01)

Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine- mediated regulation of Tiam1
by: Ramesh eChandra, et al.
Published: (2013-05-01)

D1R- and D2R-Medium-Sized Spiny Neurons Diversity: Insights Into Striatal Vulnerability to Huntington’s Disease Mutation
by: Guendalina Bergonzoni, et al.
Published: (2021-02-01)

Gap Junctions Between Striatal D1 Neurons and Cholinergic Interneurons
by: Yuqi Ren, et al.
Published: (2021-06-01)

Striatal Synapse Degeneration and Dysfunction Are Reversed by Reactivation of Wnt Signaling
by: Soledad Galli, et al.
Published: (2021-06-01)

Optogenetics reveals a role for accumbal medium spiny neurons expressingdopamine D2 receptors in cocaine-induced behavioral sensitization
by: Shelly Sooyun eSong, et al.
Published: (2014-10-01)

Signaling from the cytoplasm to the nucleus in striatal medium-sized spiny neurons
by: Miriam eMatamales, et al.
Published: (2011-07-01)

Functional analysis of newly discovered growth control genes: experimental approaches
by: R.B. Flatschart, et al.
Published: (1999-07-01)

Expanding the Model of Apathy in Parkinson's Disease: Exploration of Conceptual Domains and Identification of Neuropsychological Correlates
by: Myerson, Connie
Published: (2011)

Expression of recombinant Antibodies
by: André eFrenzel, et al.
Published: (2013-07-01)

Etudes optogénétique et pharmacologique de la connectivité et de la plasticité endocannabinoïde des synapses glutamatergiques du noyau accumbens de souris
by: Deroche, Marion
Published: (2019)

Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
by: Chi Jung Hung, et al.
Published: (2020-04-01)

Striatal direct and indirect pathways control decision-making behavior
by: Tom eMacpherson, et al.
Published: (2014-11-01)

Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules
by: Naoya Amimoto, et al.
Published: (2021-08-01)

Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons
by: Anna Kutschenko, et al.
Published: (2021-03-01)

Dopaminergic modulation of corticostriatal responses in medium spiny projection neurons from direct and indirect pathways
by: Edén eFlores-Barrera, et al.
Published: (2011-03-01)