Synthesis, in-vitro microbiological evaluation and molecular docking of novel 3,3-dimethyl-2,6-diphenyl-4-(-2-(2,4,6-trichlorophenyl) hydrazono)piperidines

• Main Authors: Govindharaju, R. (Author), Krishnasamy, K. (Author), Rajaraman, D. (Author), Sundararajan, G. (Author)
• Format: Article
• Language: English
• Published: Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma 2021
• Subjects: 1D-NMR; 2,4,6-trichlorophenyl hydrazine; 2D-NMR Spectroscopy; Antimicro-bial Activities; IR; Molecular Docking
• Online Access: View Fulltext in Publisher

 A series of novel 2,4,6-trichlorophenylhydrazines of 3,3-dimethyl-2,6-diphenyl-4-(-2-(2,4,6-trichlorophenyl)hydrazono)piperidines were synthesized and characterized by IR, Mass,1H NMR,13C NMR,1H–1H COSY and1H–13C COSY spectra. Newly synthesized compound Antimicrobial study revealed that compounds (6-9) exhibited excellent in vitro antibacterial activity against S. aureus and B. subtilis antifungal activity against C. albi-cans, C. tropicalis, A. niger and A. flavus. Molecular docking studies indicated that the synthesized compounds 6-9 possessed appreciable binding energy values against PDB ID: 3LD6 protein. It was more attractive to speculate that the result of the antimicrobial activities varied with the nature of the substituent on the 2,4,6-trichlorophenyl hydra-zine at the C-4 position. © 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.