Synthesis and characterization of co (Ii) pyridine-2,6-dicarboxylate complexes as anticancer compound

• Main Authors: Alwathoni, M. (Author), Gunawan, T. (Author), Martak, F. (Author), Mutiara, E. (Author), Soegijanto, S. (Author)
• Format: Article
• Language: English
• Published: Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma 2021
• Subjects: Anticancer Compound; BSL Test; Co (II) Complexes; Dipicolinate Ligand; Polymer Complexes; Toxicity Test
• Online Access: View Fulltext in Publisher

 In this study, two cobalt [Co(II)] Complexes were synthesized using picolinic acid (2-pyridine carbocyclic) ligand under various pH conditions. Both Complexes were characterized using FTIR, UV-Vis, XRD, CHNS microanalysis, and thermogravimetric analysis (TGA). The Complex synthesized using metal ion: ligand mol ratio of 1:1 under pH ~2 has a molecular formula of [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O. On the other hand, the Complex synthesized using the higher ligand to metal ratio of 2 at pH ~1 has a molecular formula of [CoII (H2dipic)-(dipic)].3H2O. The [CoII (dipic)(μ-dipic)-CoII (H2O)5].2H2O Complex demonstrating toxicity toward Artemia salina larvae (BSL) with the LC50 value of 5.38 ppm. Meanwhile, the [CoII (H2dipic)-(dipic)].3H2O possess an LC50 value of 8.61 ppm against the same larvae. Results showed that the Co (II)-2 Pyridine carbocyclic based Complex synthesized under acid environment demonstrating potential characteristic as anticancer cell. © 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.