Synthesis of Dihydroisoquinoline and Dihydropyridine Derivatives via Asymmetric Dearomative Three-Component Reaction

Synthesis of Dihydroisoquinoline and Dihydropyridine Derivatives via Asymmetric Dearomative Three-Component Reaction

We report the first asymmetric three-component nucleophilic addition/dearomative [4+2] cycloaddition/isomerization cascade of transient dipoles generated from N-heteroarenes and allenoates with methyleneindolinones in the presence of chiral N,N′-dioxide/metal complexes. This tandem reaction enabled...

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Bibliographic Details
Main Authors: Cao, W. (Author), Chen, M. (Author), Feng, X. (Author), He, C. (Author), Pan, G. (Author), Xiong, Q. (Author)
Format: Article
Language:English
Published: Chinese Chemical Society 2022
Subjects:
asymmetric catalysis
chiral N
dearomatization
dihydroisoquinoline
dihydropyridine
multicomponent reactions
N′-dioxide
Online Access:View Fulltext in Publisher

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