Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children

This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and severity of atopic dermatitis. Atopic dermatitis was diagnosed clinically, and severity was assessed using Ecz...

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Bibliographic Details
Main Authors: Ewertsen, C. (Author), Gerner, T. (Author), Haarup Ravn, N. (Author), Halling, A.-S (Author), Hjorslev Knudgaard, M. (Author), Jakasa, I. (Author), Kezic, S. (Author), Rasmussen Rinnov, M. (Author), Skov, L. (Author), Thyssen, J.P (Author), Trautner, S. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Online Access:View Fulltext in Publisher
LEADER 02487nam a2200505Ia 4500
001 10.2340-actadv.v102.575
008 220630s2022 CNT 000 0 und d
020 |a 16512057 (ISSN) 
245 1 0 |a Differences in Occurrence, Risk Factors and Severity of Early-onset Atopic Dermatitis among Preterm and Term Children 
260 0 |b NLM (Medline)  |c 2022 
520 3 |a This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, and severity of atopic dermatitis. Atopic dermatitis was diagnosed clinically, and severity was assessed using Eczema Area Severity Index (EASI). DNA was analysed for filaggrin gene mutations. Parents were asked about environmental exposures and emollient use. Atopic dermatitis during the first year of life was observed in 21.2% of children and was more common in term children compared with preterm children (26.7% vs 11.7%, p < 0.001), with lower age of onset (4 vs 6 months, p < 0.05) and more severe disease at onset (EASI: 4.8 vs 0.4, p < 0.0005). Environmental risk factors for atopic dermatitis were essentially similar for preterm and term born children, apart from winter and autumn births. Filaggrin gene mutations were less common in preterm than term children (4.1% vs 9.2%, p = 0.06). 
650 0 4 |a atopic dermatitis 
650 0 4 |a child 
650 0 4 |a Child 
650 0 4 |a Dermatitis, Atopic 
650 0 4 |a emollient agent 
650 0 4 |a Emollients 
650 0 4 |a genetics 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a infant 
650 0 4 |a Infant 
650 0 4 |a Infant, Newborn 
650 0 4 |a mutation 
650 0 4 |a Mutation 
650 0 4 |a newborn 
650 0 4 |a Prospective Studies 
650 0 4 |a prospective study 
650 0 4 |a risk factor 
650 0 4 |a Risk Factors 
650 0 4 |a severity of illness index 
650 0 4 |a Severity of Illness Index 
700 1 0 |a Ewertsen, C.  |e author 
700 1 0 |a Gerner, T.  |e author 
700 1 0 |a Haarup Ravn, N.  |e author 
700 1 0 |a Halling, A.-S.  |e author 
700 1 0 |a Hjorslev Knudgaard, M.  |e author 
700 1 0 |a Jakasa, I.  |e author 
700 1 0 |a Kezic, S.  |e author 
700 1 0 |a Rasmussen Rinnov, M.  |e author 
700 1 0 |a Skov, L.  |e author 
700 1 0 |a Thyssen, J.P.  |e author 
700 1 0 |a Trautner, S.  |e author 
773 |t Acta dermato-venereologica 
856 |z View Fulltext in Publisher  |u https://doi.org/10.2340/actadv.v102.575