Prevalence and factors associated with tuberculosis treatment success among TB/ HIV co-infection in north-east Malaysia

• Main Authors: Abd Wahab, F. (Author), Abdullah, S. (Author), Dir, S. (Author), Naing, N.N (Author), Tengku Jalal, T.M (Author)
• Format: Article
• Language: English
• Published: Penerbit Universiti Sains Malaysia 2017
• Subjects: adult; age; Article; BCG; clinical feature; comorbidity; cross-sectional study; demography; disease association; drug dependence; female; health center; hospital; human; Human immunodeficiency virus infection; major clinical study; Malaysia; male; mixed infection; prevalence; sex difference; social aspect; sputum smear; Successful tuberculosis treatment; TB/HIV co-infection; thorax radiography; treatment outcome; tuberculin test; Tuberculin test; tuberculosis; Tuberculosis
• Online Access: View Fulltext in Publisher; View in Scopus

 Background: One of the six strategies developed by WHO, in order to stop Tuberculosis (TB) is addressing TB/HIV high-risk groups. This study aimed to determine the prevalence of successful TB treatment and factors associated with TB treatment success among TB/HIV co-infection patients in North-East Malaysia. Methods: A cross-sectional study was carried out in the a-year period from 2003 to 2012 by reviewing TB/HIV records in all hospitals and health clinics. The outcome of interest was treatment success as defined by Ministry of Health (MOH) when the patients was cured or completed TB treatment. Results: Out of 1510 total TB/HIV co-infection cases, 27.9% (95% CI: 25.2, 30.6) of the patients were having treatment success. A majority of TB/HIV co-infection cases were male (91.1%). Fifty-eight percent the patients were drug addicts and 6% were having positive tuberculin tests. The multiple logistic regression revealed that male (OR: 0.39, 95% CI: 0.22, 0.71) and positive tuberculin test result (OR: 2.61, 95% CI: 1.63, 4.19) were significantly associated with the treatment success of TB/HIV co-infection patients. Other factors such as age, comorbid, sputum smear and x-ray findings were not significantly factors in this study. Conclusion: Female patients and those with negative tuberculin test should be emphasised for successful tuberculosis treatment. © Penerbit Universiti Sains Malaysia, 2017.