Periodontal condition and immunological aspects of individuals hospitalized in the intensive care unit

• Main Authors: Albuquerque, B.N (Author), Araújo, M.M (Author), Cortelli, S.C (Author), Costa, F.O (Author), Cota, L.O.M (Author), Silva, T.A (Author)
• Format: Article
• Language: English
• Published: Associacao Brasileira de Divulgacao Cientifica 2018
• Subjects: adult; Adult; aged; Aged; Aged, 80 and over; cardiovascular disease; Cardiovascular Diseases; complication; Cross-Sectional Studies; cross-sectional study; Cytokines; Dental Plaque Index; Diabetes Complications; diabetic complication; female; Female; gelatinase A; Gingival Crevicular Fluid; gingivitis; hospital patient; Hospitalization; human; Humans; immunology; Inpatients; intensive care unit; Intensive Care Units; interleukin 1; interleukin 6; Interleukin-1; Interleukin-6; male; Male; Matrix Metalloproteinase 2; metabolism; middle aged; Middle Aged; MMP2 protein, human; pathology; Periodontal Attachment Loss; periodontal disease; Periodontal disease; Periodontal Diseases; periodontal index; Periodontal Index; periodontal pocket; Periodontal Pocket; Periodontitis; plaque index; respiratory tract disease; Respiratory Tract Diseases; very elderly
• Online Access: View Fulltext in Publisher

 There are few studies on the clinical and immunological periodontal status of intensive care unit (ICU) in-patients. The aim of the present study was to evaluate the periodontal condition among ICU in-patients through clinical and immunological periodontal parameters. From the sample of 373 hospitalized ICU patients, 182 were submitted’ to a thorough clinical periodontal and immunological evaluation. Data on bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL) were collected and gingival sulcular fluid samples were quantified through ELISA on IL-1, IL-6, and MMP-2 for immunological evaluation. Data was statistically analyzed by Chi-square, Fisher’s exact, Mann-Whitney tests, and Sperman’s correlation and multivariate logistic regression analysis. A high dental plaque index and a high prevalence of periodontitis (48.3%), mostly in moderate and localized chronic form, were observed. Individuals with periodontitis presented higher levels of IL-1 and MMP-2, while individuals with cardiovascular disease (CVD) and individuals with two or more systemic diseases (MSD) presented higher levels of IL-1; diabetes mellitus (DM) and MSD individuals presented higher levels of IL-6. A positive association was found between the severity of periodontitis and CVD (OR 2.2; CI = 1.11-4.42). This study reported a 48.3% of the prevalence of periodontitis in ICU patients and a positive association between the severity of periodontitis and CVD. Additionally, higher levels of IL-1 and MMP-2 were found in individuals with periodontitis, higher levels of IL-6 were found in individuals with DM, and higher levels of IL-1 were found in individuals with CVD. © 2018, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.