Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

Advances in physiologically-based biokinetic (PBK) modelling, in vitro-to-in vivo extrapolation (IVIVE) methodologies, and development of permeability-limited biokinetic models have allowed predictions of tissue drug concentrations without utilizing in vivo animal or human data. However, there is a...

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Bibliographic Details
Main Authors: Chan, E.C.Y (Author), Chan, J.C.Y (Author), Tan, S.P.F (Author)
Format: Article
Language:English
Published: ALTEX Edition 2021
Subjects:
animal
Animals
Article
bile canaliculus
biliary excretion
biological model
common hepatic duct
cyclosporine
drug bioavailability
drug interaction
Drug Interactions
gene expression
human
human tissue
Humans
IC50
liver
Liver
liver weight
maximum concentration
maximum plasma concentration
Models, Biological
plasma concentration-time curve
positron emission tomography
prediction
risk assessment
rosuvastatin
Rosuvastatin Calcium
sensitivity analysis
xenobiotic agent
Xenobiotics
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