Combination treatment optimization using a pan-cancer pathway model

Combination treatment optimization using a pan-cancer pathway model

The design of efficient combination therapies is a difficult key challenge in the treatment of complex diseases such as cancers. The large heterogeneity of cancers and the large number of available drugs renders exhaustive in vivo or even in vitro investigation of possible treatments impractical. In...

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Bibliographic Details
Main Authors: Faeder, J. (Author), Farina, G. (Author), Fröhlich, F. (Author), Saglam, A.S (Author), Sandholm, T. (Author), Schmucker, R. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
algorithm
Algorithms
antineoplastic agent
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Article
biological model
biology
cancer therapy
cell population
cell proliferation
Cell Proliferation
cell viability
Computational Biology
conservative treatment
controlled study
Decision Making, Computer-Assisted
decision support system
drug effect
human
Humans
in vitro study
in vivo study
kinetic parameters
limit of quantitation
malignant neoplasm
messenger RNA
Models, Biological
Monte Carlo method
neoplasm
Neoplasms
pathology
reliability
scoring system
signal transduction
simulation
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