De novo protein fold families expand the designable ligand binding site space
A major challenge in designing proteins de novo to bind user-defined ligands with high affinity is finding backbones structures into which a new binding site geometry can be engineered with high precision. Recent advances in methods to generate protein fold families de novo have expanded the space o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |