Computational redesign of a fluorogen activating protein with Rosetta

Computational redesign of a fluorogen activating protein with Rosetta

The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, each of them went through laborious cycles of in vitr...

Full description

Bibliographic Details
Main Authors: Baranov, M.S (Author), Bender, B.J (Author), Bozhanova, N.G (Author), Gavrikov, A.S (Author), Gorbachev, D.A (Author), Harp, J.M (Author), Lukyanov, K.A (Author), Meiler, J. (Author), Mercado, C.B (Author), Mishin, A.S (Author), Zhang, X. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
amino acid sequence
Amino Acid Sequence
Article
biology
Boron Compounds
boron derivative
chemistry
chromatophore
Computational Biology
computer analysis
computer model
controlled study
Crystallography, X-Ray
drug design
Drug Design
fluorescence
Fluorescence
fluorescence imaging
fluorescence microscopy
fluorescent dye
Fluorescent Dyes
fluorogen activating protein
genetics
HEK293 cell line
HEK293 Cells
human
Humans
in vitro study
ligand binding
Luminescent Proteins
macromolecule
Microscopy, Fluorescence
Models, Molecular
molecular docking
Molecular Docking Simulation
molecular model
mutation
photoprotein
prediction
procedures
protein analysis
protein binding
protein conformation
Protein Conformation
protein engineering
Protein Engineering
protein stability
recombinant protein
Recombinant Proteins
Rosetta modeling
software
Software
unclassified drug
X ray crystallography
Online Access:View Fulltext in Publisher

Similar Items

Similar Items