Computational redesign of a fluorogen activating protein with Rosetta

The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, each of them went through laborious cycles of in vitr...

Full description

Bibliographic Details
Main Authors:	Baranov, M.S (Author), Bender, B.J (Author), Bozhanova, N.G (Author), Gavrikov, A.S (Author), Gorbachev, D.A (Author), Harp, J.M (Author), Lukyanov, K.A (Author), Meiler, J. (Author), Mercado, C.B (Author), Mishin, A.S (Author), Zhang, X. (Author)
Format:	Article
Language:	English
Published:	Public Library of Science 2021
Subjects:	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene amino acid sequence Amino Acid Sequence Article biology Boron Compounds boron derivative chemistry chromatophore Computational Biology computer analysis computer model controlled study Crystallography, X-Ray drug design Drug Design fluorescence Fluorescence fluorescence imaging fluorescence microscopy fluorescent dye Fluorescent Dyes fluorogen activating protein genetics HEK293 cell line HEK293 Cells human Humans in vitro study ligand binding Luminescent Proteins macromolecule Microscopy, Fluorescence Models, Molecular molecular docking Molecular Docking Simulation molecular model mutation photoprotein prediction procedures protein analysis protein binding protein conformation Protein Conformation protein engineering Protein Engineering protein stability recombinant protein Recombinant Proteins Rosetta modeling software Software unclassified drug X ray crystallography
Online Access:	View Fulltext in Publisher

Internet

View Fulltext in Publisher

Computational redesign of a fluorogen activating protein with Rosetta

Internet

Similar Items