Optimization of photo-biomodulation therapy for wound healing of diabetic foot ulcers in vitro and in vivo
Unclear optical parameters make photo-biomodulation (PBM) difficult to implement in diabetic foot ulcer (DFU) clinically. Here, 12 wavelengths (400-900 nm) were used to conduct PBM to heal DFU wounds in vitro and in vivo. PBM at 10 mW/cm2 and 0.5-4 J/cm2 with all 12 wavelengths promoted proliferatio...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Optica Publishing Group (formerly OSA)
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |
| LEADER | 01961nam a2200409Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1364-BOE.451135 | ||
| 008 | 220425s2022 CNT 000 0 und d | ||
| 020 | |a 21567085 (ISSN) | ||
| 245 | 1 | 0 | |a Optimization of photo-biomodulation therapy for wound healing of diabetic foot ulcers in vitro and in vivo |
| 260 | 0 | |b Optica Publishing Group (formerly OSA) |c 2022 | |
| 300 | |a 17 | ||
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1364/BOE.451135 | ||
| 520 | 3 | |a Unclear optical parameters make photo-biomodulation (PBM) difficult to implement in diabetic foot ulcer (DFU) clinically. Here, 12 wavelengths (400-900 nm) were used to conduct PBM to heal DFU wounds in vitro and in vivo. PBM at 10 mW/cm2 and 0.5-4 J/cm2 with all 12 wavelengths promoted proliferation of diabetic wound cells. In a mimic DFU (mDFU) rat model, PBM (425, 630, 730, and 850 nm, and a combination light strategy) promoted mDFU healing. The positive cell proliferation, re-epithelialization, angiogenesis, collagen synthesis, and inflammation were possible mechanisms. The combination strategy had the best effect, which can be applied clinically. © 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement | |
| 650 | 0 | 4 | |a Bio-modulation |
| 650 | 0 | 4 | |a Cell proliferation |
| 650 | 0 | 4 | |a Diabetic foot ulcer |
| 650 | 0 | 4 | |a Diabetic wounds |
| 650 | 0 | 4 | |a Diseases |
| 650 | 0 | 4 | |a In-vitro |
| 650 | 0 | 4 | |a Optical parameter |
| 650 | 0 | 4 | |a Optimisations |
| 650 | 0 | 4 | |a Rat model |
| 650 | 0 | 4 | |a Vitro and in vivo |
| 650 | 0 | 4 | |a Wound cells |
| 650 | 0 | 4 | |a Wound healing |
| 700 | 1 | |a Che, B. |e author | |
| 700 | 1 | |a Chen, Q. |e author | |
| 700 | 1 | |a Gu, Y. |e author | |
| 700 | 1 | |a Li, H. |e author | |
| 700 | 1 | |a Li, Y. |e author | |
| 700 | 1 | |a Qiu, H. |e author | |
| 700 | 1 | |a Xiafei, S. |e author | |
| 700 | 1 | |a Xiaoxi, D. |e author | |
| 700 | 1 | |a Yang, H. |e author | |
| 700 | 1 | |a Yang, J. |e author | |
| 700 | 1 | |a Yin, H. |e author | |
| 773 | |t Biomedical Optics Express | ||