Autonomic vulnerability to biased perception of social inclusion in borderline personality disorder

• Main Authors: Carlo, M. (Author), Chiara, D.P (Author), Emanuele, P. (Author), Lidia, G.M (Author), Marta, M.B.F (Author), Martina, A. (Author), Paolo, O. (Author), Paolo, R. (Author), Silvia, M. (Author), Veronica, L. (Author), Vittorio, G. (Author)
• Format: Article
• Language: English
• Published: BioMed Central Ltd 2021
• Subjects: Cyberball paradigm; Polyvagal theory; Rejection bias; Respiratory sinus arrhythmia
• Online Access: View Fulltext in Publisher
• ISBN: 20516673 (ISSN)
• DOI: 10.1186/s40479-021-00169-3

Background: Individuals with Borderline Personality Disorder (BPD) feel rejected even when socially included. The pathophysiological mechanisms of this rejection bias are still unknown. Using the Cyberball paradigm, we investigated whether patients with BPD, display altered physiological responses to social inclusion and ostracism, as assessed by changes in Respiratory Sinus Arrhythmia (RSA). Methods: The sample comprised 30 patients with BPD, 30 with remitted Major Depressive Disorder (rMDD) and 30 Healthy Controls (HC). Self-report ratings of threats toward one’s fundamental need to belong and RSA reactivity were measured immediately after each Cyberball condition. Results: Participants with BPD showed lower RSA at rest than HC. Only patients with BPD, reported higher threats to fundamental needs and exhibited a further decline in RSA after the Inclusion condition. Conclusions: Individuals with BPD experience a biased appraisal of social inclusion both at the subjective and physiological level, showing higher feelings of ostracism and a breakdown of autonomic regulation to including social scenarios. © 2021, The Author(s).