Mending a broken heart with novel cardiogenic small molecules
Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Springer
2022
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| Online Access: | View Fulltext in Publisher |
| LEADER | 01108nam a2200145Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1186-s13619-022-00120-z | ||
| 008 | 220706s2022 CNT 000 0 und d | ||
| 020 | |a 20459769 (ISSN) | ||
| 245 | 1 | 0 | |a Mending a broken heart with novel cardiogenic small molecules |
| 260 | 0 | |b Springer |c 2022 | |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1186/s13619-022-00120-z | ||
| 520 | 3 | |a Adult mammalian cardiomyocytes are unable to proliferate to regenerate lost tissue after heart injury. Du et al., reporting in Cell Stem Cell, employ a FUCCI- and MADM-based system to screen for small molecules combinations that produced a collaborative effect on cardiomyocyte cycling and cytokinesis. The authors generate a cocktail of five small molecules that increase cardiomyocyte proliferation and regeneration in vitro and in vivo with high efficiency, and explore its potential in cardiac regenerative repair after myocardial infarction through a new potential pathway for cardiomyocyte cell-cycle re-entry. © 2022, The Author(s). | |
| 700 | 1 | 0 | |a Huang, G.N. |e author |
| 700 | 1 | 0 | |a Powers, N. |e author |
| 773 | |t Cell Regeneration | ||