Diversity in EWAS: current state, challenges, and solutions

Diversity in EWAS: current state, challenges, and solutions

Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generatio...

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Bibliographic Details
Main Authors: Beck, S. (Author), Berndt, S.I (Author), Breeze, C.E (Author), Franceschini, N. (Author), Wong, J.Y.Y (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
article
DNA methylation
epigenome
letter
Online Access:View Fulltext in Publisher
Description
Summary:Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis. © 2022, The Author(s).
ISBN:1756994X (ISSN)
DOI:10.1186/s13073-022-01065-3

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