Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed. One approach in this regard a...

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Bibliographic Details
Main Authors: Bartosik, A. (Author), Bender, A. (Author), Dolciami, D. (Author), Elbasir, A. (Author), Liu, A. (Author), Walter, M. (Author), Wright, P. (Author), Yang, H. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2021
Subjects:
biological model
Chemical and Drug Induced Liver Injury
computer simulation
Computer Simulation
Drug-induced liver injury (DILI)
human
Humans
machine learning
Machine Learning
Mechanistic models
Models, Biological
Protein target
Structural alerts
toxic hepatitis
Online Access:View Fulltext in Publisher

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