Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

Background: Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function and memory in mouse models, but Pyk2 deletion has minimal effect on neuro-i...

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Bibliographic Details
Main Authors: Brody, A.H (Author), Guan, F. (Author), Lam, T.K.T (Author), Lee, S. (Author), Mukherjee, B. (Author), Nies, S.H (Author), Salazar, S.A (Author), Smith, L.M (Author), Strittmatter, S.M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Alzheimer’s disease
C1q
Fronto-temporal dementia
PTK2B
Pyk2
Tauopathy
Online Access:View Fulltext in Publisher

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