The glomus tumor resorbed bone and teeth in the mandible: A case report

• Main Authors: Kurohara, K. (Author), Michi, Y. (Author), Yamaguchi, S. (Author), Yukimori, A. (Author)
• Format: Article
• Language: English
• Published: BioMed Central Ltd. 2018
• Subjects: adult; Adult; Biopsy, Needle; case report; Case report; diagnostic imaging; follow up; Follow-Up Studies; glomus tumor; Glomus tumor; Glomus Tumor; human; Humans; immunohistochemistry; Immunohistochemistry; male; Male; Mandible; mandible tumor; Mandibular Neoplasms; needle biopsy; Neoplasm Recurrence, Local; oral surgery; Oral Surgical Procedures; panoramic radiography; pathology; procedures; Radiography, Panoramic; rare disease; Rare Diseases; Recurrence; reoperation; Reoperation; Resorption of teeth roots; risk assessment; Risk Assessment; treatment outcome; Treatment Outcome; tumor recurrence
• Online Access: View Fulltext in Publisher

 Background: A glomus tumor is a rare neoplasm usually found in the dermis or subcutaneous tissue of the extremities. It is rare for the glomus tumor to occur on the head and face. Only 26 glomus tumors of the oral region and affected bone have been reported in the English-language literature (Table 1). We report a case of a glomus tumor at the mandible. As a new point, the glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible. Case presentation: The patient was a 44-year-old Japanese man who complained swelling of the right mandible. Radiographic examination showed a multilocular radiolucency area in the left mandible. Radiographic findings on our case resembled those of a common benign tumor. The lesion occupied to the premolar and molar area and revealed that the tumor resorbed the roots of the teeth. The lesion was removed surgically with the buccal cortical bone and buccal mucosa in contact with the mass of the tumor. The mass fully excised intraorally under general anesthesia, and the inferior alveolar nerve in contact with the mass was preserved. The specimen was pathologically diagnosed as a glomus tumor. Immunohistochemical staining was positive for vimentin, muscle-specific actin/HHF35, and calponin. A hairline-shaped area of positive staining for type IV collagen surrounding the tumor cells was also observed. In contrast, staining for alpha-SMA, cytokeratin (AE1/AE3), cytokeratin (CAM5.2), CK19, CD31, CD34, CD68, p63, S-100, Factor VIII, and desmin was all negative. The Ki-67 labeling index was almost 1%. A recurrent tumor was again detected in the site below the primary tumor at an 8-year follow-up, and it was surgically removed. The patient has had no symptoms of recurrence in 2years after the second operation. Conclusion: The glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible. The immunohistochemical features of the tumor were consistent with those described in previous reports. It is important to completely remove the Glomus tumor. © 2018 The Author(s).