Changes of retinal ganglion cell complex after vitrectomy in rhegmatogenous retinal detachment patients and its correlation with inflammatory blood biomarkers

• Main Authors: Ai, M. (Author), Chen, T. (Author), Chen, W. (Author), Lei, M. (Author), Song, J. (Author), Zuo, W. (Author)
• Format: Article
• Language: English
• Published: BioMed Central Ltd 2022
• Subjects: Ganglion cell complex; Inflammatory blood biomarker; Rhegmatogenous retinal detachment; Silicone oil; Vitrectomy
• Online Access: View Fulltext in Publisher

 Purpose: To compare retinal ganglion cell complex (GCC) parameters between rhegmatogenous retinal detachment (RRD) eyes and normal contralateral eyes after vitrectomy and to evaluate their correlation with inflammatory blood markers. Methods: We investigated 25 eyes that underwent vitrectomy due to RRD. Venous blood samples were collected from all participants before 08:00 a.m. on the second day of admission after a 12-hour fast for blood counts. The differences of retinal structure between RRD and contralateral eyes were compared 1 week postoperatively. Results: Focal loss volume (FLV) (2.009 ± 1.286)% was significantly increased compared with the contralateral eyes (p < 0.001). Monocyte-to-high-density lipoprotein was significantly positively correlated with GCC thickness parameters, and negatively correlated with FLV and global loss volume (GLV). Postoperative best-corrected visual acuity was negatively correlated with GLV (p = 0.039, R2 = 0.172). Conclusion: Retinal ganglion cells (RGCs) loss might present early postoperatively in RRD eyes, and was associated with systemic inflammation. RGCs loss might affect postoperative vision. © 2022, The Author(s).