Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms

Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms

Background: Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms differ in the size of these cytoplasmic domains. In view of the...

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Bibliographic Details
Main Authors: Ampe, C. (Author), Hirano, S. (Author), Hochepied, T. (Author), Kleinberger, I. (Author), Lemeire, K. (Author), Martens, L. (Author), Sanders, E. (Author), Staes, K. (Author), van Roy, F. (Author), Van Troys, M. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Allografts
Conditional gene knockout
GFAP-Cre
Mouse auricular tumors
Mouse medulloblastoma model
Protocadherin-10 isoforms
RNA-Seq
Somatic stem cells
Tumor suppression
Tumor-derived cells
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