Estimation of total mediation effect for high-dimensional omics mediators
Background: Environmental exposures can regulate intermediate molecular phenotypes, such as gene expression, by different mechanisms and thereby lead to various health outcomes. It is of significant scientific interest to unravel the role of potentially high-dimensional intermediate phenotypes in th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BioMed Central Ltd
2021
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |