The prognostic value of an autophagy-related lncRNA signature in hepatocellular carcinoma

• Main Authors: Fu, J. (Author), Wang, L. (Author), Yang, L. (Author), Yang, S. (Author), Zhang, X. (Author), Zhao, X. (Author), Zhou, Y. (Author)
• Format: Article
• Language: English
• Published: BioMed Central Ltd 2021
• Subjects: autophagy; Autophagy; Autophagy-related lncRNAs; Biological process; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell death; Chemical analysis; child; Child; Child, Preschool; Combined analysis; Cox regression analysis; genetics; Hepatocellular carcinoma; High-risk patients; human; Humans; infant; Infant; liver cell carcinoma; Liver Neoplasms; liver tumor; long untranslated RNA; Multivariant analysis; Prediction accuracy; preschool child; prognosis; Prognosis; Risk assessment; RNA; RNA, Long Noncoding; Targeted treatment; The Risk prediction model; Therapeutic targets; tumor marker
• Online Access: View Fulltext in Publisher

 Background: lncRNA may be involved in the occurrence, metastasis, and chemical reaction of hepatocellular carcinoma (HCC) through various pathways associated with autophagy. Therefore, it is urgent to reveal more autophagy-related lncRNAs, explore these lncRNAs’ clinical significance, and find new targeted treatment strategies. Methods: The corresponding data of HCC patients and autophagy genes were obtained from the TCGA database, and the human autophagy database respectively. Based on the co-expression and Cox regression analysis to construct prognostic prediction signature. Results: Finally, a signature containing seven autophagy-related lncRNAs (PRRT3-AS1, RP11-479G22.8, RP11-73M18.8, LINC01138, CTD-2510F5.4, CTC-297N7.9, RP11-324I22.4) was constructed. Based on the risk score of signature, Overall survival (OS) curves show that the OS of high-risk patients is significantly lower than that of low-risk patients (P = 2.292e−10), and the prognostic prediction accuracy of risk score (AUC = 0.786) is significantly higher than that of ALBI (0.532), child_pugh (0.573), AFP (0.5751), and AJCC_stage (0.631). Moreover, multivariate Cox analysis and Nomogram of risk score are indicated that the 1-year and 3-year survival rates of patients are obviously accuracy by the combined analysis of the risk score, child_pugh, age, M_stage, and Grade (The AUC of 1- and 3-years are 0.87, and 0.855). Remarkably, the 7 autophagy-related lncRNAs may participate in Spliceosome, Cell cycle, RNA transport, DNA replication, and mRNA surveillance pathway and be related to the biological process of RNA splicing and mRNA splicing. Conclusion: In conclusion, the 7 autophagy-related lncRNAs might be promising prognostic and therapeutic targets for HCC. © 2021, The Author(s).