Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

Targeting fatty acid amide hydrolase (FAAH) is a promising therapeutic strategy to combat certain forms of pain, including migraine headache. FAAH inhibitors, such as the O-biphenyl-3-yl carbamate URB597, have been shown to produce anti-hyperalgesic effects in animal models of migraine. The objectiv...

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Bibliographic Details
Main Authors: Demartini, C. (Author), Francavilla, M. (Author), Greco, R. (Author), Piomelli, D. (Author), Realini, N. (Author), Reggiani, A. (Author), Scarpelli, R. (Author), Tassorelli, C. (Author), Zanaboni, A.M (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
FAAH inhibitors
Lipid-derived mediators
NTG
Trigeminal hyperalgesia
Online Access:View Fulltext in Publisher

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