P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine

Migraine is the second most common form of headache disorder and the second leading cause of disability worldwide. Cognitive symptoms ranked second resulting in migraine-related disability, after pain. P2X7 receptor (P2X7R) was recently shown to be involved in hyperalgesia in migraine. However, the...

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Bibliographic Details
Main Authors: Fan, S. (Author), Hu, L. (Author), Li, W. (Author), Shan, Z. (Author), Wang, Y. (Author), Xiao, Z. (Author), Zhang, L. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: BioMed Central Ltd 2022
Subjects:
Apoptosis
Cognitive impairment
Migraine
Neuroinflammation
NLRP3 inflammasome
P2X7 receptor
Pyroptosis
Online Access:View Fulltext in Publisher

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