Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

Tcf1 is essential for initiation of oncogenic Notch1-driven chromatin topology in T-ALL

NOTCH1 is a well-established lineage specifier for T cells and among the most frequently mutated genes throughout all subclasses of T cell acute lymphoblastic leukemia (T-ALL). How oncogenic NOTCH1 signaling launches a leukemia-prone chromatin landscape during T-ALL initiation is unknown. Here we de...

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Main Authors: Alonso-Moreno, S. (Author), Antoszewski, M. (Author), Belver, L. (Author), Ciriello, G. (Author), Dubey, C. (Author), Ferrando, A.A (Author), Fournier, N. (Author), Huijbers, I.J (Author), Koch, U. (Author), Liu, Y. (Author), Lourenco, J. (Author), Nkosi, M. (Author), Pritchard, C.E.J (Author), Radtke, F. (Author), Ruiz Buendía, G.A (Author), Segat, G.C (Author), Serracanta, E. (Author), Sugrue, T. (Author), Weng, A.P (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Online Access:View Fulltext in Publisher

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