Styryl lactones from roots and barks goniothalamus lanceolatus

• Main Authors: Abdullah, F. (Author), Ahmad, F.B (Author), Awang, K. (Author), Bihud, N.V (Author), Ismail, N.H (Author), Mai, C.-W (Author), Rasol, N.E (Author)
• Format: Article
• Language: English
• Published: Natural Product Incorporation 2018
• Subjects: 5 acetylgoniothalamin; 5 hydroxy 6 styryltetrahydropyrane 2 one; 5 hydroxygoniothalamin; antineoplastic activity; antineoplastic agent; Article; bark; colon cancer cell line; cytotoxicity; Cytotoxicity; deoxygoniopypyrone b; diastereoisomer; goniodiol 7 monoacetate; goniodiol 8 monoacetate; goniofupyrone b; Goniothalamus; Goniothalamus lanceolatus; Goniothalamus lanceolatus extract; human; human cell; IC50; lactone derivative; lung cancer cell line; MTT assay; plant extract; plant root; proton nuclear magnetic resonance; Sarawak; Styryl lactones; unclassified drug
• Online Access: View Fulltext in Publisher; View in Scopus
• ISBN: 1934578X (ISSN)
• DOI: 10.1177/1934578x1801301203

A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8S-goniodiol-7-monoacetate 5, 6S,7S,8S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1S,5S,7R,8S,3-endo,7-endo-(+)-8-epi-9-deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10-15) were also isolated and characterized. 6S-goniothalamin 1 is reported for the first time from a Goniothalamus species. 1, 11 and 12 showed cytotoxic activity against human colon and lung cancer cell lines with IC50 values ranging from 2.38-7.59 µM. Copyright © 2018 Natural Product Incorporation. All rights reserved..