Antioxidant and anticholinesterase activities of essential oils of cinnamomum griffithii and C. macrocarpum

• Main Authors: Ahmad, F. (Author), Salleh, W.M.N.H.W (Author), Yen, K.H (Author)
• Format: Article
• Language: English
• Published: Natural Product Incorporation 2015
• Subjects: acetylcholinesterase; Acetylcholinesterase; alpha cubebene; alpha ylangene; Anticholinesterase; antioxidant; Antioxidant; antioxidant activity; Antioxidants; aromadendrene; Article; bark; beta patchoulene; beta pinene; borneol; butylcresol; camphor; caryophyllene oxide; chemistry; cholinesterase inhibition; cholinesterase inhibitor; Cholinesterase Inhibitors; Cinnamomum; Cinnamomum griffithi; Cinnamomum griffithii; Cinnamomum griffithii extract; Cinnamomum macrocarpum; Cinnamomum macrocarpum extract; controlled study; copaene; dehydroaromadendrene; drug identification; drug isolation; elemicin; essential oil; Essential oil; galantamine; gamma selinene; gas chromatography; Gas Chromatography-Mass Spectrometry; germacrene D; isolation and purification; limonene; longifolene; mass fragmentography; nonhuman; Oils, Volatile; para cymene; plant extract; plant leaf; Plant Oils; safrole; spathulenol; terpinene; terpineol; unclassified drug; unindexed drug; valencene; vegetable oil
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 The essential oils of Cinnamomum griffithii and C. macrocarpum were analyzed by GC and GC-MS and evaluated for their antioxidant and anticholinesterase activities. The essential oils of leaf and bark of C. griffithii were characterized by the presence of 30 components, with methyl eugenol (38.5-43.8%) as the major component. A total of 11 components were characterized in the leaf and bark of C. macrocarpum essential oil with the most abundant component was safrole (54.5-59.5%). The bark oil of C. griffithii demonstrated significant activity on DPPH (IC50 73.4 μg/mL) and a high phenolic content (192.0%), while the leaf oil inhibited oxidation of β-carotene/linoleic acid with an inhibition value of 65.5 μg/mL. Acetylcholinesterase and butyrylcholinesterase inhibition were assessed and the results showed that C. macrocarpum bark oil exhibited significant activity with inhibition values of 55.8% and 66.1%, respectively at a concentration of 1 mg/mL.