LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin Pathways

LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin Pathways

Introduction: Hepatocellular carcinoma and hepatoblastoma are two liver cancers characterized by gene deregulations, chromosomal rearrangements, and mutations in Wnt/beta-catenin (Wnt) pathway-related genes. LHX2, a transcriptional factor member of the LIM homeobox gene family, has important functio...

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Main Authors: Armengol, C. (Author), Avignon, C. (Author), Carrillo-Reixach, J. (Author), Caruso, S. (Author), Del Rio-Alvarez, A. (Author), Dubois, E. (Author), Dugot-Senant, N. (Author), Fedou, S. (Author), Grosset, C.F (Author), Guettier, C. (Author), Khoubai, F.Z (Author), Mosca, N. (Author), Mussini, C. (Author), Thiébaud, P. (Author), Veschambre, P. (Author), Zucman-Rossi, J. (Author)
Format: Article
Language:English
Published: S. Karger AG 2022
Subjects:
Hepatoblastoma
Hepatocellular carcinoma
LHX2
MAPK/ERK pathway
Wnt pathway
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