In Vitro Evaluations and in Vivo Toxicity and Efficacy Studies of MFM501 against MRSA

In Vitro Evaluations and in Vivo Toxicity and Efficacy Studies of MFM501 against MRSA

Previously we have discovered a synthetically derived pyrrolidone alkaloid, MFM501, exhibiting good inhibitory activity against 53 MRSA and MSSA isolates with low cytotoxicity against three normal cell-lines with IC50 values at >625 μg/ml. Time-kill assay, scanning electron microscopy (SEM) analy...

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Bibliographic Details
Main Authors: Johari, S.A (Author), Mohamad Ridhwan, M.J (Author), Mohamed, A. (Author), Mohammat, M.F (Author), Mohtar, M. (Author), Sahdan, R. (Author), Syed Mohamad, S.A (Author)
Format: Article
Language:English
Published: Hindawi Limited 2017
Subjects:
acute toxicity
animal
animal experiment
animal model
Animals
Anti-Bacterial Agents
antibiotic agent
antiinfective agent
Article
bacterial cell
cell membrane
cell surface
controlled study
drug effects
drug efficacy
extracellular matrix
human
Humans
in vitro study
in vivo study
methicillin resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
mfm 501
MFM501
Mice
microbial sensitivity test
Microbial Sensitivity Tests
microbiology
Microscopy, Electron, Scanning
minimum inhibitory concentration
mouse
nonhuman
pathogenicity
peritonitis
pyrrolizidine alkaloid
Pyrrolizidine Alkaloids
scanning electron microscopy
Staphylococcal Infections
Staphylococcus infection
toxicity testing
ultrastructure
unclassified drug
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