In vitro inhibitory and cytotoxic activity of MFM 501, a Novel codonopsinine derivative, against methicillin-resistant Staphylococcus aureus clinical isolates

In vitro inhibitory and cytotoxic activity of MFM 501, a Novel codonopsinine derivative, against methicillin-resistant Staphylococcus aureus clinical isolates

28 new pyrrolidine types of compounds as analogues for natural polyhydroxy alkaloids of codonopsinine were evaluated for their anti-MRSA activity using MIC and MBC value determination assay against a panel of S. aureus isolates. One pyrrolidine compound, MFM 501, exhibited good inhibitory activity w...

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Bibliographic Details
Main Authors: Hamzah, A.S (Author), Johari, S.A (Author), Mohammat, M.F (Author), Mohtar, M. (Author), Sahdan, R. (Author), Shaameri, Z. (Author), Syed Mohammad, S.A (Author)
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2015
Subjects:
alkaloid
Alkaloids
Anti-Bacterial Agents
antibiotic agent
antiinfective agent
apoptosis
Apoptosis
Article
bactericidal activity
bacteriostasis
bacterium isolation
cell survival
Cell Survival
chemistry
clinical evaluation
codonopsinine
controlled study
cytology
cytotoxicity
dose response
Dose-Response Relationship, Drug
drug effects
drug safety
drug screening
IC50
in vitro study
in vivo study
methicillin resistant Staphylococcus aureus
methicillin susceptible Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
mfm 501
microbial sensitivity test
Microbial Sensitivity Tests
minimum bactericidal concentration
minimum inhibitory concentration
nonhuman
physiology
pyrrolidine derivative
Pyrrolidines
reaction analysis
Staphylococcus aureus
structure activity relation
unclassified drug
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