Structure-aware mycobacterium tuberculosis functional annotation uncloaks resistance, metabolic, and virulence genes

Structure-aware mycobacterium tuberculosis functional annotation uncloaks resistance, metabolic, and virulence genes

Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome annotation of Mycobacterium tuberculosis virule...

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Bibliographic Details
Main Authors: Baughn, A.D (Author), Chan, C.K (Author), Dhillon, N. (Author), Dillon, N.A (Author), Elghraoui, A. (Author), Gunasekaran, D. (Author), Kuo, N. (Author), Modlin, S.J (Author), Robinhold, C. (Author), Valafar, F. (Author), Zlotnicki, A.M (Author)
Format: Article
Language:English
Published: American Society for Microbiology 2021
Subjects:
antibiotic agent
antibiotic resistance
Article
bacterial enzyme
bacterial gene
bacterial genome
bacterial protein
bacterial virulence
bacterium mutant
carrier protein
coenzyme A
controlled study
drug efficacy
drug metabolism
Mycobacterium tuberculosis
nonhuman
Protein Data Bank
protein structure
pyrazinamide
transposon
tuberculosis
type strain
virulence factor
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