Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus

Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) significantly increases bone fragility and fracture risk. Progranulin (PGRN) promotes bone fracture healing in both physiological and type 1 diabetic conditions. The present study aimed to investigate the role of PGRN in T2DM bone fracture healing. MKR mice (with an F...

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Bibliographic Details
Main Authors: Ding, Y. (Author), Einhorn, T.A (Author), Hettinghouse, A. (Author), Li, G. (Author), Li, X. (Author), Liu, C.-J (Author), Wei, J. (Author)
Format: Article
Language:English
Published: Blackwell Publishing Inc. 2021
Subjects:
acan protein
anabolic agent
Anabolic Agents
animal
animal cell
animal experiment
animal model
animal tissue
Animals
antiinflammatory activity
Article
bone development
bone marrow cell
bone regeneration
Bone Regeneration
callus
cell isolation
chondrogenesis
clinical assessment
col2a1 protein
collagen sponge
collagen type 2
complementary DNA
controlled study
cyclooxygenase 2
cytoplasm protein
Diabetes Mellitus, Type 2
drug effect
drug mechanism
enchondral ossification
fracture
fracture healing
Fracture Healing
Fractures, Bone
glucose
glyceraldehyde 3 phosphate dehydrogenase
human
Humans
immunohistochemistry
impaired fracture healing
in vitro study
in vivo study
inducible nitric oxide synthase
interleukin 1beta
ketamine
male
messenger RNA
metabolism
Mice
Mice, Transgenic
mitogen activated protein kinase 1
mitogen activated protein kinase 3
mitogen activated protein kinase p38
molecular biology
mouse
non insulin dependent diabetes mellitus
nonhuman
Osteogenesis
pathology
progranulin
Progranulins
protein expression
protein kinase B
real time polymerase chain reaction
Receptors, Tumor Necrosis Factor, Type II
reverse transcription polymerase chain reaction
RNA extraction
signal transduction
somatomedin C
staining
stress activated protein kinase
tissue section
Tnf protein, mouse
Tnfrsf1b protein, mouse
TNF-α
transcription factor RelA
transgenic mouse
tumor necrosis factor
tumor necrosis factor receptor
tumor necrosis factor receptor 2
tumor necrosis factor receptors
Tumor Necrosis Factor-alpha
type 2 diabetes
unclassified drug
upregulation
Western blotting
xylazine
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