Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells

Inhibition of matrix metalloproteinase-2 modulates malignant behaviour of oral squamous cell carcinoma cells

Background: Matrix metalloproteinases (MMPs) play a crucial role in the malignant phenotype of cancer cells. In particular, active levels of MMP2 in cancer cells have been associated with invasion and metastasis through the degradation of basement membrane extracellular matrix proteins. However, lit...

Full description

Bibliographic Details
Main Authors:	Celentano, A. (Author), Cirillo, N. (Author), Koo, K. (Author), McCullough, M. (Author), Mirams, M. (Author), Paolini, R. (Author), Yap, T. (Author), Yiannis, C. (Author)
Format:	Article
Language:	English
Published:	Blackwell Publishing Ltd 2021
Subjects:	adult arp 101 Article cancer grading cancer tissue carcinogenesis Carcinoma, Squamous Cell cell invasion cell invasion assay Cell Line, Tumor cell migration cell motion Cell Movement cell proliferation cell survival cell viability controlled study enzyme inhibition female gelatinase A H357 cell line H400 cell line Head and Neck Neoplasms head and neck tumor histopathology human human cell human tissue Humans immunohistochemistry in vitro study keratinocytes major clinical study male matrigel Matrix Metalloproteinase 2 matrix metalloproteinase inhibitor matrix metalloproteinases messenger RNA middle aged MMP2 monoclonal antibody monoclonal antibody MA513590 Mouth Neoplasms mouth squamous cell carcinoma mouth tumor neutralizing antibody oral cancer oral squamous cell carcinoma cell line priority journal protein expression squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck tissue microarray transwell assay tumor cell line unclassified drug
Online Access:	View Fulltext in Publisher

Similar Items

Microneedle-mediated Intratumoral Delivery of Anti-CTLA-4 Promotes cDC1-dependent Eradication of Oral Squamous Cell Carcinoma with Limited irAEs
by: Gilardi, M., et al.
Published: (2022)

Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas
by: Ye. V. Klisho, et al.
Published: (2011-02-01)

Matrix Metalloproteinases: The Gene Expression Signatures of Head and Neck Cancer Progression
by: Shinji Iizuka, et al.
Published: (2014-02-01)

Establishment and Characterization of Primary Cultures from Iranian Oral Squamous Cell Carcinoma Patients by Enzymatic Method and Explant Culture
by: Meysam Ganjibakhsh, et al.
Published: (2017-10-01)

Basaloid squamous cell carcinoma of the head and neck: Our experience
by: Jaimanti Bakshi, et al.
Published: (2020-01-01)

Prognostic Significance of MMP2 and MMP9 Functional Promoter Single Nucleotide Polymorphisms in Head and Neck Squamous Cell Carcinoma
by: Samaneh Hajihoseini, et al.
Published: (2011-03-01)

ΔNp63α promotes Bortezomib resistance via the CYGB–ROS axis in head and neck squamous cell carcinoma
by: Song, X., et al.
Published: (2022)

Prevalence of Head and Neck Cancer in Gilan Province, Iran: A 10-Year Study
by: F Shahsavari, et al.
Published: (2017-07-01)

Immunohistochemical Study of Metalloproteinases (MMP-2 and MMP-9) Expression in Laryngeal Squamous Cell Carcinoma
by: Zeinab Yehia Abdel-Meguid, et al.
Published: (2019-07-01)

Spindle cell variant squamous cell carcinoma of the oral cavity: Case presentation and review of literature
by: Benjamin Palla, et al.
Published: (2020-09-01)

MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC)
by: Masashi Shiiba, et al.
Published: (2010-04-01)

Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands
by: Bruggink, A.H, et al.
Published: (2022)

Vasculogenic Mimicry: A Promising Prognosticator in Head and Neck Squamous Cell Carcinoma and Esophageal Cancer? A Systematic Review and Meta-Analysis
by: Roosa Hujanen, et al.
Published: (2020-02-01)

Epidemiological aspects of head and neck cancers in a population of south east region of Iran
by: Hamideh Kadeh, et al.
Published: (2015-09-01)

Matrix metalloproteinase‐14 (MMP‐14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation
by: Nanzheng Chen, et al.
Published: (2020-11-01)

Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: an immunohistochemical study
by: Túlio Morandin Ferrisse, et al.
Published: (2021-01-01)

Tinospora crispa extract inhibits MMP-13 and migration of head and neck squamous cell carcinoma cell lines
by: Hataipan Phienwej, et al.
Published: (2015-09-01)

Differential Angiogenic Potential of 3-Dimension Spheroid of HNSCC Cells in Mouse Xenograft
by: So-Young Choi, et al.
Published: (2021-07-01)

The immune phenotype of tongue squamous cell carcinoma predicts early relapse and poor prognosis
by: Giuseppe Troiano, et al.
Published: (2020-11-01)

Dorsal spinal metastases secondary to squamous cell carcinoma tongue: A rare case report and review of literature
by: Vikas Maheshwari, et al.
Published: (2021-01-01)

P2 purinergic receptor signaling and interleukin-1 synergistically induce interleukin-6 production in a human oral squamous carcinoma cell line
by: Kuroishi, T., et al.
Published: (2021)

Digital Pathology Scoring of Immunohistochemical Staining Reliably Identifies Prognostic Markers and Anatomical Associations in a Large Cohort of Oral Cancers
by: Julius Moratin, et al.
Published: (2021-07-01)

Evaluation of therapeutic efficacy with CytoSorter® circulating tumor cell–capture system in patients with locally advanced head and neck squamous cell carcinoma
by: Zheng W, et al.
Published: (2019-06-01)

Variations in protein expression associated with oral cancer
by: Chen, W., et al.
Published: (2023)

Immunotherapy and its advances in the management of head-and-neck cancer
by: Sajad Ahmad Buch, et al.
Published: (2019-01-01)

SOX7 blocks vasculogenic mimicry in oral squamous cell carcinoma
by: Chawla, K., et al.
Published: (2021)

DNA Methylation and HPV-Associated Head and Neck Cancer
by: Takuya Nakagawa, et al.
Published: (2021-04-01)

Heart breaking diagnosis: Cardiac metastases from mucosal head and neck squamous cell carcinoma. Case report and review of current literature
by: Karuna Dewan, et al.
Published: (2020-11-01)

Second primary cancer in patients with head and neck squamous cell carcinoma (review of the literature)
by: G O Agabekyan, et al.
Published: (2014-06-01)

Cancer Stem Cells in Oral Cavity Squamous Cell Carcinoma: A Review
by: Ranui Baillie, et al.
Published: (2017-06-01)

MMP2 as an independent prognostic stratifier in oral cavity cancers
by: Caroline Hoffmann, et al.
Published: (2020-01-01)

Oral cancer in patients of the province of Las Tunas, a 7-year study
by: Tomás Ramón de-la-Paz-Suárez, et al.
Published: (2018-05-01)

Prognostic and Clinicopathological Significance of FADD Upregulation in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
by: Miguel Ángel González-Moles, et al.
Published: (2020-08-01)

Field cancerization in stomatognathic system
by: Vidya Kadashetti, et al.
Published: (2016-01-01)

MAPKs activation in head and neck squamous cell carcinomas
by: Daniele Maggioni, et al.
Published: (2011-11-01)

Comment from the Editor on the Special Issue “Head and Neck Critical Illness: Basic and Clinical Research Implications”
by: Hiroyuki Tomita
Published: (2019-11-01)

Specific Characteristics of Head and Neck Squamous Cell Carcinoma in Mures Area
by: Réka Fejér Enikő, et al.
Published: (2015-09-01)

Human papillomavirus 16–positive supraclavicular cutaneous squamous cell carcinoma metastatic to the level IV supraclavicular lymph nodes
by: Hannah Dekker, MD, DDS, et al.
Published: (2020-09-01)

Characterization of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy
by: Xinhai Zhang, et al.
Published: (2020-12-01)

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx
by: Petr Čelakovský, et al.
Published: (2015-08-01)