New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy

• Main Authors: Abourehab, M.A.S (Author), Afzal, S. (Author), Hasan, H. (Author), Hussain, Z. (Author), Safdar, M.H (Author), Thu, H.E (Author)
• Format: Article
• Language: English
• Published: Taylor and Francis Ltd. 2018
• Subjects: animal; Animals; Anti-cancer agents; antineoplastic activity; antineoplastic agent; Antineoplastic Agents; Biocompatibility; breast cancer; Cancer; cancer therapy; CD44 overexpression; Cell death; chemistry; colorectal cancer; conjugation; Controlled drug delivery; Delivery vehicle; Diagnosis; Diseases; drug delivery system; Drug Delivery Systems; drug design; drug development; drug effect; drug resistance; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene therapy; head and neck cancer; Hermes antigen; human; Humans; hyaluronic acid; Hyaluronic acid; Hyaluronic Acid; improved anticancer efficacy; liver cell carcinoma; lung cancer; malignant neoplasm; Medical nanotechnology; metabolism; multidrug resistance; Multidrug resistance; nanocarrier; nanomedicine; nanomedicines; neoplasm; Neoplasms; Oncology; Organic acids; ovary carcinoma; Over-expression; pancreas carcinoma; pathology; procedures; Review; skin cancer; stomach cancer; Surface modulations; Targeted drug delivery; Tumors; Tumour progression; tumour-specific targetability; uterine cervix cancer
• Online Access: View Fulltext in Publisher; View in Scopus
• ISBN: 21691401 (ISSN)
• DOI: 10.1080/21691401.2017.1397001

This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in cancer therapy, various hyaluronic acid (HA)-conjugated nanomedicines have been fabricated owing to their biocompatibility, safety, tumour-specific targetability of drugs and genes, and proficient interaction with cluster-determinant-44 (CD44) receptors over-expressed on the surface of tumour cells. HA-based conjugation or surface modulation of anticancer drugs encapsulated nanocarriers have shown promising efficacy against the various types of carcinomas of liver, breast, colorectal, pancreatic, lung, skin, ovarian, cervical, head and neck and gastric. The success of this emerging platform is assessed in achieving the rapid internalization of anticancer payloads into the tumour cells, impeding cancer cells division and proliferation, induction of cancer-specific apoptosis and prevention of metastasis (tumour progression). This review extends detailed insight into the engineering of HA-based nanomedicines, characterization, utilization for the diagnosis or treatment of CD44 over-expressing cancer subtypes and emphasizing the transition of nanomedicines to clinical cancer therapy. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.