Semisynthesis and cytotoxic activities of andrographolide analogues

Semisynthesis and cytotoxic activities of andrographolide analogues

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Andrographolide 1, a diterpenoid lactone of the plant Andrographis paniculata, known to possess antitumour activity in in vitro and in vivo breast cancer models was subjected to semisynthesis leading to the preparation of a number of novel compounds. These compounds exhibited in vitro antitumour act...

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Bibliographic Details
Main Authors: Hamzah, A.S (Author), Jada, S.R (Author), Lajis, N.H (Author), Saad, M.S (Author), Stanslas, J. (Author), Stevens, M.F.G (Author)
Format: Article
Language:English
Subjects:
3,19 (2 bromobenzylidene)andrographolide
3,19 (2 chloro 4 fluorobenzylidene)andrographolide
3,19 (2 chloro 5 nitrobenzylidene)andrographolide
3,19 (2 chlorobenzylidene)andrographolide
3,19 (2 ethoxy 4 hydroxybenzylidene)andrographolide
3,19 (2 fluorobenzylidene)andrographolide
3,19 (2 hydroxy 3 methoxybenzylidene)andrographolide
3,19 (2 hydroxy 5 nitrobenzylidene)andrographolide
3,19 (2 methylbenzylidene)andrographolide
3,19 (2 nitrobenzylidene)andrographolide
3,19 (2,5 dimethoxybenzylidene)andrographolide
3,19 (3 bromobenzylidene)andrographolide
3,19 (3 chloro 4 fluorobenzylidene)andrographolide
3,19 (3 chlorobenzylidene)andrographolide
3,19 (3 fluorobenzylidene)andrographolide
3,19 (3 hydroxy 4 methoxybenzylidene)andrographolide
3,19 (3 methylbenzylidene)andrographolide
3,19 (3 nitrobenzylidene)andrographolide
3,19 (3,4 dihydroxybenzylidene)andrographolide
3,19 (3,4 dimethoxybenzylidene)andrographolide
3,19 (3,5 dimethoxybenzylidene)andrographolide
3,19 (4 bromobenzylidene)andrographolide
3,19 (4 chlorobenzylidene)andrographolide
3,19 (4 fluorobenzylidene)andrographolide
3,19 (4 methylbenzylidene)andrographolide
3,19 (4 nitrobenzylidene)andrographolide
Andrographis paniculata
andrographolide
Andrographolide
andrographolide derivative
antineoplastic activity
antineoplastic agent
Antineoplastic Agents, Phytogenic
article
cancer cell culture
cancer inhibition
cell culture
Cell Line, Tumor
cell strain HCT116
cell strain MCF 7
concentration response
cytotoxicity
Cytotoxicity
Diterpenes
drug potency
Drug Screening Assays, Antitumor
drug selectivity
drug structure
drug synthesis
human
human cell
Humans
in vitro study
incubation time
infrared spectrometry
LC 50
MTT assay
National Cancer Institute (NCI)
priority journal
proton nuclear magnetic resonance
Semisynthesis
structure activity relation
Structure-Activity Relationship
unclassified drug
unindexed drug
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