Polypill with or without aspirin in persons without cardiovascular disease

BACKGROUND A polypill comprising statins, multiple blood-pressure-lowering drugs, and aspirin has been proposed to reduce the risk of cardiovascular disease. METHODS Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART...

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Bibliographic Details
Main Authors:	Bosch, J. (Author), Christou, C. (Author), Dagenais, G. (Author), Dans, A. (Author), Gamra, H. (Author), Gao, P. (Author), Girish, P. (Author), Joseph, P. (Author), Lopez-Jaramillo, P. (Author), McCready, T. (Author), Pais, P. (Author), Rocha, C. (Author), Santoso, A. (Author), Talukder, S. (Author), Teo, K. (Author), Tyrwhitt, J. (Author), Xavier, D. (Author), Xavier, F. (Author), Yeates, K. (Author), Yusoff, K. (Author), Yusuf, S. (Author)
Format:	Article
Language:	English
Published:	Massachussetts Medical Society 2021
Series:	New England Journal of Medicine
Subjects:	acetylsalicylic acid adult aged Aged Anticholesteremic Agents antihypertensive agent Antihypertensive Agents antithrombocytic agent Article Aspirin atenolol Atenolol blood blood pressure Blood Pressure cardiovascular disease Cardiovascular Diseases cardiovascular mortality cerebrovascular accident Cholesterol, LDL clinical outcome clinical trial combination drug therapy controlled study dizziness double blind procedure drug combination Drug Combinations drug effect drug safety Drug Therapy, Combination drug withdrawal dyspepsia female Female follow up gastritis gastrointestinal hemorrhage heart arrest heart failure heart infarction heart muscle revascularization human Humans hydrochlorothiazide Hydrochlorothiazide hypocholesterolemic agent hypotension incidence Incidence low density lipoprotein cholesterol low density lipoprotein cholesterol level low drug dose male Male Medication Adherence medication compliance middle aged Middle Aged mortality multicenter study muscle disease peptic ulcer placebo Platelet Aggregation Inhibitors priority journal ramipril randomized controlled trial risk factor Risk Factors simvastatin Simvastatin systolic blood pressure vitamin D
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Polypill with or without aspirin in persons without cardiovascular disease

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