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10.1038-s41526-022-00195-7 |
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|a 23738065 (ISSN)
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|a Bone strength and composition in spacefaring rodents: systematic review and meta-analysis
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|b Nature Research
|c 2022
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|z View Fulltext in Publisher
|u https://doi.org/10.1038/s41526-022-00195-7
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|a Studying the effects of space travel on bone of experimental animals provides unique advantages, including the ability to perform post-mortem analysis and mechanical testing. To synthesize the available data to assess how much and how consistently bone strength and composition parameters are affected by spaceflight, we systematically identified studies reporting bone health in spacefaring animals from Medline, Embase, Web of Science, BIOSIS, and NASA Technical reports. Previously, we reported the effect of spaceflight on bone architecture and turnover in rodents and primates. For this study, we selected 28 articles reporting bone strength and composition in 60 rats and 60 mice from 17 space missions ranging from 7 to 33 days in duration. Whole bone mechanical indices were significantly decreased in spaceflight rodents, with the percent difference between spaceflight and ground control animals for maximum load of −15.24% [Confidence interval: −22.32, −8.17]. Bone mineral density and calcium content were significantly decreased in spaceflight rodents by −3.13% [−4.96, −1.29] and −1.75% [−2.97, −0.52] respectively. Thus, large deficits in bone architecture (6% loss in cortical area identified in a previous study) as well as changes in bone mass and tissue composition likely lead to bone strength reduction in spaceflight animals. © 2022, The Author(s).
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|a Bone architecture
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|a Bone strength
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|a Composition parameters
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|a Experimental animals
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|a Mammals
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|a Mechanical testing
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|a Meta-analysis
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|a NASA
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|a Postmortem analysis
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|a Rock mechanics
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|a Space travel
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|a Spacefaring
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|a Strength parameters
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|a Systematic Review
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|a Condon, S.F.
|e author
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|a Crooks, S.D.
|e author
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|a Goldsmith, M.
|e author
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|a Komarova, S.V.
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|a Willie, B.M.
|e author
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|t npj Microgravity
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