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01618nam a2200145Ia 4500 |
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10.1038-s41522-022-00302-2 |
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220706s2022 CNT 000 0 und d |
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|a 20555008 (ISSN)
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| 245 |
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|a Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring
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| 260 |
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|b Nature Research
|c 2022
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| 856 |
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|z View Fulltext in Publisher
|u https://doi.org/10.1038/s41522-022-00302-2
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|a The probiotic bacterium Lactobacillus plantarum is often reckoned as a ‘generalist’ for its ability to adapt and survive in diverse ecological niches. The genomic signatures of L. plantarum have shown its intricate evolutionary ancestry and dynamic lifestyles. Here, we report on a unique geometrical arrangement of the multicellular population of L. plantarum cells. Prominently, a phenomenon of the cone-shaped colony formation and V-shaped cell chaining are discovered in response to the acidic-pH environment. Moreover, subsequent cold stress response triggers an unusual cellular arrangement of consolidated bundles, which appeared to be independently governed by a small heat shock protein (HSP 1). We further report that the V-shaped L. plantarum chaining demonstrates potent antagonistic activity against Candida albicans, a pathogenic yeast, both in vitro and in a Caenorhabditis elegans co-infection model. Finally, we deduce that the multifaceted traits manifested by this probiotic bacterium is an outcome of its dynamic flexibility and cellular heterogeneity. © 2022, The Author(s).
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| 700 |
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|a Rajasekharan, S.K.
|e author
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| 700 |
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|a Shemesh, M.
|e author
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| 773 |
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|t npj Biofilms and Microbiomes
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