Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair

Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair

DNA ligase I (LIG1) catalyzes the ligation of the nick repair intermediate after gap filling by DNA polymerase (pol) β during downstream steps of the base excision repair (BER) pathway. However, how LIG1 discriminates against the mutagenic 3′-mismatches incorporated by polβ at atomic resolution rema...

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Bibliographic Details
Main Authors:	Çağlayan, M. (Author), Gulkis, M. (Author), McKenna, R. (Author), Tang, Q. (Author)
Format:	Article
Language:	English
Published:	Nature Research 2022
Online Access:	View Fulltext in Publisher

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