CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids

The Hedgehog (HH) pathway is critical for development and adult tissue homeostasis. Aberrant HH signaling can lead to congenital malformations and diseases including cancer. Although cholesterol and several oxysterol lipids have been shown to play crucial roles in HH activation, the molecular mechan...

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Bibliographic Details
Main Authors: Agnew, C. (Author), Jura, N. (Author), Klein, O.D (Author), Li, A. (Author), Lo, M. (Author), Marangoni, P. (Author), Neben, C. (Author), Paul, M.D (Author), Raleigh, D.R (Author), Sharir, A. (Author), Torosyan, H. (Author), Xu, L. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Online Access:View Fulltext in Publisher

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