Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing

Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing

Bloom syndrome (BS) is associated with a profoundly increased cancer risk and is caused by mutations in the Bloom helicase (BLM). BLM is involved in the nucleolytic processing of the ends of DNA double-strand breaks (DSBs), to yield long 3' ssDNA tails that serve as the substrate for break repa...

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Bibliographic Details
Main Authors: Burma, S. (Author), Greene, E.C (Author), Kawale, A.S (Author), Kwon, Y. (Author), Salunkhe, S.J (Author), Sung, P. (Author), Tomimatsu, N. (Author), Xue, C. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Online Access:View Fulltext in Publisher

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