Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic dissemination. Removal of senescent tumor cells (se...

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Bibliographic Details
Main Authors: Alimonti, A. (Author), Attanasio, G. (Author), Bolis, M. (Author), Cippà, P. (Author), Colucci, M. (Author), D’Ambrosio, M. (Author), Guccini, I. (Author), Mosole, S. (Author), Pasquini, E. (Author), Revandkar, A. (Author), Rinaldi, A. (Author), Troiani, M. (Author), Valdata, A. (Author), Varesi, A. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
apoptosis
cancer
cell
genetic analysis
inhibitor
rodent
senescence
tumor
vulnerability
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