Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or “cancer-killing” viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeutic drugs for the treatment of cancer. In this study,...

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Main Authors: Alkayyal, A. (Author), Alluqmani, N. (Author), Auer, R.C (Author), Austin, B. (Author), Azad, T. (Author), Bell, J.C (Author), Boileau, M. (Author), Boutros, P.C (Author), Brown, E.E.F (Author), Chatterjee, A. (Author), Cottee, M.L (Author), Crawford, N. (Author), Crupi, M.J.F (Author), de Souza, C.T (Author), Diallo, J.-S (Author), Geoffrion, M. (Author), Gibbings, D. (Author), He, X. (Author), Ilkow, C.S (Author), Jacobus, E.J (Author), Jamieson, T. (Author), Jennings, V.A (Author), Keller, B.A (Author), Khan, S.T (Author), Laight, B.J (Author), Mansfield, D. (Author), McKay, H.E (Author), McSweeney, B. (Author), Melcher, A. (Author), Migneco, G. (Author), Pelin, A. (Author), Petryk, J. (Author), Pikor, L. (Author), Poutou, J. (Author), Pugliese, G. (Author), Rayner, K.J (Author), Rezaei, R. (Author), Rose, E. (Author), Roy, D.G (Author), Singaravelu, R. (Author), Surendran, A. (Author), Taha, Z. (Author), tenOever, B.R (Author), Wedge, M.-E (Author), Yamaguchi, T.N (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
RNA
Online Access:View Fulltext in Publisher